Clinical Resource Center

Self-Administered Skills-Based Virtual Reality Intervention for Chronic Pain: Randomized Controlled Pilot Study

Patients with chronic pain often have limited access to comprehensive care that includes behavioral pain management strategies. Virtual reality (VR) is an immersive technology and emerging digital behavioral pain therapy with analgesic efficacy for acute pain.

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Self-Administered Behavioral Skills–Based At-Home Virtual Reality Therapy for Chronic Low Back Pain: Protocol for a Randomized Controlled Trial

Chronic pain is one of the most common and debilitating health conditions. Treatments for chronic low back pain typically focus on biomedical treatment approaches. While psychosocial treatments exist, multiple barriers prevent broad access. There is a significant unmet need for integrative, easily accessible, non-opioid solutions for chronic pain.

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An 8-Week Self-Administered At-Home Behavioral Skills-Based Virtual Reality Program for Chronic Low Back Pain: Double-Blind, Randomized, Placebo-Controlled Trial Conducted During COVID-19

Chronic low back pain is the most prevalent chronic pain condition worldwide and access to behavioral pain treatment is limited. Virtual reality (VR) is an immersive technology that may provide effective behavioral therapeutics for chronic pain.

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Three-Month Follow-Up Results of a Double-Blind, Randomized Placebo-Controlled Trial of 8-Week Self-Administered At-Home Behavioral Skills-Based Virtual Reality (VR) for Chronic Low Back Pain

Prior work established post-treatment efficacy for an 8-week home-based therapeutic virtual reality (VR) program in a double-blind, parallel arm, randomized placebo-controlled study. Participants were randomized 1:1 to 1 of 2 56-day VR programs: 1) a therapeutic immersive pain relief skills VR program; or 2) a Sham VR program within an identical commercial VR headset.

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Durability of the Treatment Effects of an 8-Week Self-administered Home-Based Virtual Reality Program for Chronic Low Back Pain: 6-Month Follow-up Study of a Randomized Clinical Trial

We previously reported the efficacy of an 8-week home-based therapeutic immersive virtual reality (VR) program in a double-blind randomized placebo-controlled study. Community-based adults with self-reported chronic low back pain were randomized 1:1 to receive either (1) a 56-day immersive therapeutic pain relief skills VR program (EaseVRx) or (2) a 56-day sham VR program.

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In-home virtual reality program for chronic low back pain: durability of a randomized, placebo-controlled clinical trial to 18 months post-treatment

Chronic low back pain (CLBP) impacts approximately one-third of adults globally. Efficacious non-pharmacological and behavioral treatments for CLBP are needed, but barriers impede broad implementation, such as the need for therapists, treatment duration, insurance coverage, and copay requirements.

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Durable chronic low back pain reductions up to 24 months after treatment for an accessible, 8-week, in-home behavioral skills–based virtual reality program: a randomized controlled trial

Chronic low back pain (cLBP) is prevalent worldwide. Durably effective, in-home behavioral interventions could meet the need for nonpharmacological pain care, as emphasized by the US Centers for Disease Control and Prevention (CDC) and US Centers for Medicare and Medicaid Services (CMS).

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In-Home Virtual Reality Program for Chronic Lower Back Pain: A Randomized Sham-Controlled Effectiveness Trial in a Clinically Severe and Diverse Sample

To determine whether an 8-week, self-administered in-home, behavioral skills virtual reality program for chronic low back pain (RelieVRx) that trains diaphragmatic breathing, biofeedback, cognition and emotion regulation, mindfulness, and pain education skills, is superior to a strong active Sham at day 56 for improving pain intensity and pain interference, in a large real-world sample.

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Digital Therapeutics (DTx) Expand Multimodal Treatment Options for Chronic Low Back Pain: The Nexus of Precision Medicine, Patient Education, and Public Health

Digital therapeutics (DTx, software as a medical device) provide personalized treatments for chronic diseases and expand precision medicine beyond pharmacogenomics-based pharmacotherapies. In this perspective article, we describe how DTx for chronic low back pain (CLBP) can be integrated with pharmaceutical drugs (e.g., NSAIDs, opioids), physical therapy (PT), cognitive behavioral therapy (CBT), and patient empowerment.

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Use and efficacy of virtual, augmented, or mixed reality technology for chronic pain: a systematic review

Characterize use and efficacy/effectiveness of virtual, augmented, or mixed reality (VR/AR/MR) technology as non-pharmacological therapy for chronic pain.

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Virtual Reality in the Treatment of Adults with Chronic Low Back Pain: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Virtual reality (VR) can present advantages in the treatment of chronic low back pain. The objective of this systematic review and meta-analysis was to analyze the effectiveness of VR in chronic low back pain.

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Socio-Demographic Predictors of Clinical Effectiveness, Therapeutic Program Engagement, and Device Usability for An In-Home Virtual Reality Program for Chronic Low Back Pain: Secondary Analysis of a Randomized Controlled Trial

Healthcare inequities are well established in chronic pain care. Promising immersive digital therapeutics like RelieVRx®, an FDA-authorized, proprietary Skills-Based virtual reality (VR) for chronic pain program, may transcend such barriers by offering in-home access with no Wi-Fi connectivity required, and easy to use, gaze-based navigation and therapeutic delivery.

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Perspective: The Promise of Virtual Reality as an Immersive Therapeutic

In this perspective, we discuss the promise of virtual reality (VR) as an immersive therapeutic (ITx) delivery device. We review the neurobiology of learning and show that VR broadly engages multiple learning systems in the brain in synchrony thus having the unique potential to increase the effectiveness and speed of therapeutic change. We examine one application of VR in the delivery of chronic pain management therapy. 

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New Breakthroughs in Chronic Pain

Heath Haug served for 22 years in the Army, Marine Corps and National Guard, followed by two decades as a cop. “I beat my body up,” he says. “My back, feet, my knee. It takes a toll.”

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AppliedVR and Kernel Flow Announce Clinical Results Evaluating How Brain Changes During Virtual Reality Treatment of Chronic Pain

AppliedVR®, a medical device pioneer advancing a novel, virtual reality-based approach to medicine, and Kernel today announced a joint study measuring the impact of VR pain treatment on the brain. The study, which included a single-blind, sham-controlled design, compared brain activation patterns and physiological metrics before, during, and after VR experiences in people experiencing chronic low back pain (CLBP).

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Indication for Use The RelieVRx program is a prescription-use immersive virtual reality system intended to provide adjunctive treatment based on cognitive behavioral therapy skills and other evidence-based behavioral methods for patients (age 18 and older) with a diagnosis of chronic lower back-pain (defined as moderate to severe pain lasting longer than three months). The device is intended for in-home use for the reduction of pain and pain interference associated with chronic lower back pain.

Contraindications

There are no known contraindications.